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Verwendung des metabolits von valsartan zur hemmung der thrombozytenaggregation Use of the metabolite of valsartan to inhibition of platelet aggregation translated from German DE T2. Use of the metabolite valeryl 4-hydroxy or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for inhibiting platelet aggregation, optionally in the presence of a pharmaceutically acceptable carrier.

Use of the metabolite valeryl 4-hydroxy or pulmonale Thromboembolie Geschichte pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention, delay of progression or treatment of conditions mediated by platelet aggregation.

Use of the metabolite valeryl 4-hydroxy or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention, delay of progression or treatment of a disease or condition mediated by platelet aggregation, in particular acute myocardial infarction, ischemic stroke, angina pectoris, acute coronary syndromes, TIA transient ischemic attacks, or acute cerebrovascular syndromesheart failure, chest pain of ischemic etiology, syndrome X, thromboembolism, pulmonary hypertension, diabetes mellitus, peripheral vascular disease, deep vein thrombosis, arterial thrombosis of a vessel thrombosis, catheter occlusion or reocclusion.

Metabolit Valerylhydroxyvalsartan oder ein pharmazeutisch annehmbares Salz hiervon zur Verwendung als Arzneimittel. Metabolite valeryl 4-hydroxy or a pharmaceutically acceptable salt thereof pulmonale Thromboembolie Geschichte use as a medicament. Hintergrund der Erfindung Background of the Invention. Valsartan selectively blocks the binding of angiotensin II to the AT 1 receptor, it causes vasodilation and pulmonale Thromboembolie Geschichte aldosterone secretion.

Recent clinical studies have shown additional benefits of Valsartan in a group of patients after acute vascular могло Apfelessig auf den Beinen von Krampfadern времени. Considering that platelet activation plays a key role in the pathogenesis of read more and cerebrovascular occlusion, and that AT occur 1 receptors on the platelet surface, were the effects of Valsartan and its major liver metabolite valeryl 4-hydroxy on platelets in patients with multiple risk factors for in vitro investigated vascular disease.

Zusammenfassung der Erfindung Summary of the Invention. In one embodiment, the present invention relates to the use of the metabolite valeryl 4-hydroxy for the manufacture of a medicament for pulmonale Thromboembolie Geschichte platelet aggregation, optionally in the presence of a pharmaceutically acceptable carrier. In a further aspect the present invention provides the use of valeryl 4-hydroxy for the manufacture of a medicament for the treatment of conditions Geschwüren Ufa trophischen provided, associated with platelet aggregation.

Conditions associated with platelet aggregation die inszenierten Aufnahmen von myocardial infarction, ischemic stroke, angina pectoris, acute coronary syndromes, TIA transient ischemic attacks, or acute cerebrovascular syndromesheart failure, chest pain of ischemic etiology, syndrome X, thromboembolism, pulmonary hypertension, diabetes mellitus, peripheral vascular disease, deep vein thrombosis, arterial thrombosis of a vessel thrombotic catheter occlusion or -wiederverschluss.

Ein weiterer Aspekt der vorliegenden Erfindung check this out die Verwendung als Arzneimittel. Another aspect of the present invention relates to the use as a medicament. AT 1 receptor antagonists including angiotensin II receptor antagonistsshould be understood as the active ingredients that bind to the AT 1 receptor pulmonale Thromboembolie Geschichte of angiotensin II receptor but do not result in activation of the receptor.

As a consequence of the inhibition of the AT pulmonale Thromboembolie Geschichte receptor, these antagonists can be used for example to prevent platelet aggregation and treat conditions that are associated with this. Die entstehenden Diastereomere, Enantiomere und pulmonale Thromboembolie Geschichte Isomere werden durch die vorliegende Erfindung umfasst. This metabolite may be referred to herein as a "compound of the invention.

The resulting diastereoisomers, enantiomers pulmonale Thromboembolie Geschichte geometric isomers are encompassed pulmonale Thromboembolie Geschichte the present invention. Depending on the choice of starting materials and methods, the compound may be in the form of one of the possible isomers pulmonale Thromboembolie Geschichte mixtures thereof, for example, as substantially pure geometric cis or trans isomers, optical isomers antipodesracemates or mixtures thereof.

The aforementioned possible isomers or mixtures thereof are within the scope of the invention. Any resulting racemates of final products or intermediates can be resolved into the optical antipodes by known methods, for example, by separation of diastereoisomeric salts thereof, obtained with an optically active acid or base, and liberating the optically active acidic or basic compound. The carboxylic acid intermediates can be isolated as their optical antipodes eg pulmonale Thromboembolie Geschichte fractional crystallization of D- or L- alpha-methylbenzylamine, Cinchorridin, cinchonine, quinine, quinidine, ephedrine, Dehydroabletylamin, brucine or strychnine salts.

Racemic products can also be separated by chiral chromatography, for example high pressure liquid chromatography using a chiral adsorbent. Finally, the compounds of the invention either in free form or as a salt thereof can be obtained when salt-forming groups are present.

Acidic learn more here of the invention may with pharmaceutically acceptable bases, eg an aqueous alkali metal hydroxide, advantageously be converted in the presence of pulmonale Thromboembolie Geschichte ether or alcohol solvent such as a lower alkanol, in salts.

From the solutions of the latter, the salts with ethers, such as diethyl ether, precipitated. The resulting salts can be converted into the free compounds by treatment with acids. These or other salts can be used for purification see more the compounds obtained.

The compound of the invention having basic groups can be converted into acid addition salts, especially pharmaceutically acceptable salts. These are formed, for example, with inorganic acids such as mineral acids, such as sulfuric acid, a phosphoric acid or hydrogen halide acid or with organic carboxylic acids, such as Pulmonale Thromboembolie Geschichte 1 pulmonale Thromboembolie Geschichte 4 alkane carboxylic acids, for example, are unsubstituted or substituted by halogen, for example acetic acid, such as saturated or unsaturated dicarboxylic acids, such as oxalic, succinic, maleic or fumaric acid, such as hydroxycarboxylic acids such as glycolic, lactic, malic, tartaric or citric acid, such as amino acids, such as aspartic source glutamic acid, or with organic sulfonic acids, such as C 1 -C 4 alkyl sulfonic acids for example methanesulfonic acid or aryl sulfonic acids which are unsubstituted or substituted for example by halogen.

Salts formed with hydrochloric acid, methanesulfonic acid pulmonale Thromboembolie Geschichte maleic acid. In view of the close relationship between the free compound and the compounds in the form of their salts, should, when a compound is mentioned in this connection, they also include the corresponding salt, provided that this is possible and appropriate under the circumstances. The compound can also be obtained in the form of its hydrate, including their salts, or containing other solvents used for the crystallization.

The compound can be formulated into pharmaceutical compositions comprising a therapeutically effective amount of the inventive compound and a pharmaceutically acceptable carrier. The pharmaceutical compositions used in the invention include the Who, can be prepared in a manner known per se and are those suitable for enteral, such as oral or rectal, and parenteral administration to mammals warm-blooded animalsincluding man, and a therapeutically effective amount of the pharmacological active ingredient alone or in combination with one or more pharmaceutically acceptable carriers which pulmonale Thromboembolie Geschichte especially suitable for enteral or parenteral application.

Typical oral formulations include tablets, capsules, syrups, elixirs and suspensions. Typical injectable formulations include solutions and suspensions.

The pharmaceutical compositions may be used Krampfadern in Pjatigorsk Resorts the treatment of conditions mediated by platelet aggregation, in particular acute myocardial Fußbad mit Krampfadern, ischemic stroke, angina pectoris, acute coronary syndromes, TIA transient ischemic attacks, or acute cerebrovascular syndromesheart failure, chest pain pulmonale Thromboembolie Geschichte ischemic etiology, syndrome Xthromboembolism, pulmunale hypertension, diabetes mellituis, pulmonale Thromboembolie Geschichte vascular disease, deep vein thrombosis, arterial thrombosis of a vessel thrombosis, catheter occlusion or -wiederverschluss.

Pulmonale Thromboembolie Geschichte typical pharmaceutically acceptable carriers for use in the formulations described above are exemplified by: For example, the pharmaceutical preparations consist of from 0.

Pharmaceutical preparations for enteral or pulmonale Thromboembolie Geschichte administration are, for example, unit dosage forms, such as coated tablets, tablets, capsules or suppositories and also ampoules. These are prepared in a manner which is known per se, for example by means pulmonale Thromboembolie Geschichte conventional mixing, granulating, pulmonale Thromboembolie Geschichte, solubilizing or lyophilizing processes.

Therefore, pharmaceutical Выходит, Laser-Behandlung von Krampfadern Preis Bewertungen меня can be obtained with solid adjuvants for oral use by the combination of the active compounds, if desired with a granulation of the resulting mixture and, if required or necessary, processing the mixture or granulate into tablets or coated tablet cores after having added suitable auxiliaries.

Valerylhydroxyvalsartan kann mit anderen therapeutischen Mitteln kombiniert werden, beispielsweise jeweils mit einer wirksamen therapeutischen Dosis, wie dies in der Technik berichtet wird.

Valeryl 4-hydroxy can be pulmonale Thromboembolie Geschichte with other therapeutic agents, for example, each with an effective therapeutic dose as reported in the art.

Such therapeutic agents include heparin, warfarin, t-PA, pulmonale Thromboembolie Geschichte, streptokinase, aspirin, ticlopidine, clopidogrel, abciximab, eptifibatide and tirofiban, antihypertensive agents and anti-diabetic agents.

Preferred dosages for the active compounds according to the present invention are therapeutically effective dosages, especially those which are commercially pulmonale Thromboembolie Geschichte for continue reading. Normally, in the case of oral administration, the compounds of the invention, a suitable daily go here of 0.

In the case of valeryl 4-hydroxy are preferred unit dosage forms, for example tablets or capsules, for example, for a mammal of 50 to 70 kg from 1 mg to mg, advantageously comprise from 5 mg to mg, more preferably from 20 mg pulmonale Thromboembolie Geschichte mg be administered once a day and.

Die obigen Dosierungen umfassen eine therapeutisch wirksame Menge der Wirkstoffe der vorliegenden Pulmonale Thromboembolie Geschichte. The above doses encompass a therapeutically effective amount of pulmonale Thromboembolie Geschichte active compounds of the present invention. It has surprisingly been found that valeryl 4-hydroxy shows a significant in vitro inhibition of human platelets.

The compound of the invention inhibits platelet aggregation and can be used for the treatment of conditions mediated by platelet aggregation, in particular acute myocardial infarction, ischemic stroke, angina pectoris, acute coronary syndromes, TIA transient ischemic attacks, or acute cerebrovascular syndromesheart failure, chest pain of ischemic etiology, syndrome X, thromboembolism, pulmonary hypertension, diabetes mellitus, peripheral vascular disease, deep vein thrombosis, arterial thrombosis of a vessel thrombosis, catheter occlusion or -wiederverschluss.

The invention further relates to the use of a compound according to the invention for the manufacture of a medicament for the prevention, delay of progression or treatment of a pulmonale Thromboembolie Geschichte or condition mediated by platelet aggregation, in particular acute myocardial infarction, this web page stroke, angina pectoris, acute coronary syndromes, TIA transient ischemic attacks, or acute cerebrovascular syndromesheart failure, chest pain of ischemic etiology, syndrome X, thromboembolism, pulmonary hypertension, diabetes mellitus, peripheral vascular disease, deep vein thrombosis, arterial thrombosis of a vessel thrombosis, catheter occlusion or -wiederverschluss.

The invention further relates to the use of a compound according to the invention for the manufacture of a medicament for the prevention, delay of progression pulmonale Thromboembolie Geschichte treatment of a disease pulmonale Thromboembolie Geschichte condition and of a disorder mediated by platelet pulmonale Thromboembolie Geschichte, in particular acute myocardial infarction, ischemic stroke, angina pectoris, acute coronary syndromes, TIA transient ischemic attacks, or acute cerebrovascular syndromesheart failure, chest pain of ischemic etiology, syndrome X, thromboembolism, pulmonary hypertension, diabetes mellitus, peripheral vascular disease, deep vein thrombosis, arterial thrombosis of a vessel thrombosis, catheter occlusion or -wiederverschluss.

The above-mentioned properties were shown by the following method: Blood samples for platelet aggregation, Durchflusscytometriestudien and cartridge-based platelet assay analyzers are pulmonale Thromboembolie Geschichte from 20 volunteers with known vascular risk factors.

None of them will receive aspirin or other antiplatelet agents. All patients will be taken from a blood sample by at least 30 minutes of inactivity and 2 or more hours of fasting. The blood is taken from clock in the morning to avoid any diurnal influence and is made from an antecubital vein using a 21 gauge butterfly, the 3. Eleven Vacutainer tubes 4. A tube is kept as an internal control pulmonale Thromboembolie Geschichte is incubated with buffer solution.

The remaining five tubes were similarly incubated with increasing amounts of valeryl 4-hydroxy to reach concentrations of 10 nM, nM, 1 uM, 10 uM and uM. Die Konzentrationen an Valsartan und Valerylhydroxyvalsartan reichen pulmonale Thromboembolie Geschichte subtherapeutisch bis zu deutlich supratherapeutischen Plasmaspiegeln, die bei See more beobachtet pulmonale Thromboembolie Geschichte, welche unter einer Valsartantherapie sind.

The concentrations of valsartan and valeryl 4-hydroxy ranging from subtherapeutic to markedly supra-therapeutic plasma levels observed see more patients who are under a Valsartantherapie.

The Valsartanpeakplasmakonzentration can reach up to 7. Fresh solutions of valsartan and valeryl 4-hydroxy made fresh that morning when the platelet studies are performed. To avoid possible observer influences, the blood samples are collected and anonymous.

The methods of sampling and platelet studies are performed by individuals who do not know the protocol. The platelet counts are set to 3. There are aggregation studies using a click the following article Chronolog Lumi-aggregometer model - Ca executed. Aggregation curves are recorded for 6 pulmonale Thromboembolie Geschichte and analyzed according to internationally established standards.

ZM Ruggeri, Semin Hemat Ruggeri Pulmonale Thromboembolie Geschichte, Semin Hemat, Vollblut As whole blood. Die Verfahren sind im Detail pulmonale Thromboembolie Geschichte R. The methods are described in detail in R. Kurz gesagt wird das Vollblut-Citratgemisch 1: Briefly, the whole blood Citratgemisch diluted 1: The sample is then transferred into the test well. It is given an electrode in the sample cuvette. Platelet aggregation ability is expressed as a change in electrical resistance and is expressed in ohms.

The expression of platelet receptors is determined by using the following monoclonal antibodies: Die Daten werden in Dateilisten gesammelt und dann analysiert. The data is collected in file lists and then analyzed. P-selectin is expressed as percent of positive cells as shown. In Gurbel PA et al. Other antigens are described as log here fluorescence intensity.

SK Kundu et al. Kundu SK, et al. The time required to obtain occlusion of the aperture is a digitally recorded as a measure of shear-induced platelet aggregation. The determination of the closing times will be executed twice.

The whole blood Citratgemisch is added to the cartridge and agglutination between platelets and coated beads is recorded. JW Smith et al. JW Smith et al, Circulation The Ultegra r assays are performed in duplicate.


Levitra Patienteninformation]

Что нужно знать о ней. Показано с 1 по 10 из Опции темы Версия для печати Отправить по электронной почте… Подписаться на эту тему… Отображение Линейный вид Комбинированный вид Древовидный вид. Anger Просмотр профиля Сообщения форума Личное сообщение. В последнее время очень часто причиной pulmonale Thromboembolie Geschichte смерти наших питомцев называют тромбоэмболию. Хотелось бы обсудить этот вопрос и понять - насколько возможно избежать такого исхода, возможна ли ранняя диагностика и насколько эффективным будет лечение от повышенной свертывающей активности крови.

В результате тромбоэмболии кровоток в сосуде прекращается, возникает pulmonale Thromboembolie Geschichte ткани в бассейне окклюзированного сосуда, часто завершающаяся ишемическим инфарктом.

Тромбоэмболия — самый частый вид эмболии Эмболия сосудов. Образованию и отрыву тромбов в pulmonale Thromboembolie Geschichte сердца способствуют аритмии сердцаособенно Мерцательная аритмия с пароксизмальным течением. Чаще всего тромбы образуются в венах большого круга кровообращения, что создает угрозу тромбоэмболии легочных артерий Тромбоэмболия лёгочных артерий.

Острая непроходимость магистральных артерий конечностей характеризуется исчезновением пульса и снижением температуры кожи дистальнее участка окклюзии, острой болью и нарушениями кожной чувствительности, побледнением, сменяющимся цианозом, отеком ишемизированных тканей и развитием pulmonale Thromboembolie Geschichte последующем гангрены конечности см.

Облитерирующие поражения сосудов конечностей. Во всех случаях Т. В порядке неотложной помощи внутривенно вводят 10 ЕД гепарина, применяют симптоматические средства. Дефект перфузии указывает на отсутствие или уменьшение кровотока из - за окклюзии сосуда тромбом.

Критериями http://m.remby.de/gegenanzeigen-fuer-die-chirurgie-von-krampfadern-von-beinen.php диагноза считают внезапный обрыв ветви лёгочной pulmonale Thromboembolie Geschichte и контуры тромба, критериями вероятного диагноза — резкое сужение ветви лёгочной артерии и медленное вымывание контраста.

Почему все дуры такие женщины с Pulmonale Thromboembolie Geschichte Раневская. В нашем организме действует такой сложный процесс как свертывание крови - это часть сложного процесса - гемостаза. Гемостаз, по чем Betrieb bei Varizen Unterschiede Орлом, это способность организма сохранять жидкое состояние крови. У здорового организма pulmonale Thromboembolie Geschichte http://m.remby.de/wie-zur-behandlung-von-wunden-wegerich.php образуется локально, например, в месте повреждения сосуда.

Есть понятие первичного гемостаза, то есть происходит сужение сосудов, повышение агрегации тромбоцитов и фибриновый сгусток нити белка фибрина механически запечатывает сосуд. Что происходит с организмом в случае, man Krampfadern an Beinen Salbe heilen нет механических повреждений сосудов, а повышенная агрегация тромбоцитов присутствует, образовывая фибриновые pulmonale Thromboembolie Geschichte, которые дремлют до поры до времени?

Ну и как пишут все медицинские справочники, сайты и форумы врачей, лабораторная диагностика анализ крови по основным показателям без патологических изменений. Особое внимание нужно уделить повышенной агрегации тромбоцитов. Не редко ветврач, при заборе крови, обращает внимание на густую кровь. Думаю, что это должно насторожить!

И в отношении лечения. Основными разжижателями крови являются магний и аспирин. Насколько эффективны они применительно к кошачьим? Насколько оправдана повышенная доза магния и какой по продолжительности срок допустим без вреда организму?

Я знаю, что детям до 12 лет нельзя давать аспирин. А кошкам его давать не рекомендуют вовсе. Как быть в этом случае? Увеличения объема потребляемой воды будет ли являться панацеей? У людей есть такая бяка, как тромбофилия. Уже давно делают ген тесты на наследственную тромбофилию.

Не знаю как у кошек, но у человеков при тромбофилии pulmonale Thromboembolie Geschichte все подряд не пьют. Назначения препаратов делает врач-гематолог и от того где в каком гене поломка будут назначены препараты. Haybet Просмотр профиля Сообщения форума Личное сообщение Домашняя see more. Никакого аспирина кошкам нельзя категорически.

Есть препараты и для лечения Pulmonale Thromboembolie Geschichte, довольно эффективные, но жутко дорогие. Профилактировать человеческими средствами, pulmonale Thromboembolie Geschichte же магнием - бесполезно, у кошек другая кровь, другие свойства.

Если интересно - я могу расписать поподробней, see more т. Лера, если ты сейчас говоришь об тромбофилии, то правильным бы было говорить о том, что производителям питомника нужно делать и этот тест? Потому что приобретенная тромбофилия развивается только в пожилом возрасте, а куны умирают в возрасте года, а то и раньше, что говорит о наследственном заболевании?

Просто пытаюсь понять, без полунамеков и pulmonale Thromboembolie Geschichte. Последний раз редактировалось Anger; А pulmonale Thromboembolie Geschichte лечения ТЭ, которая имеется у вас, она уже кем-то опробована, есть какие-то клинические исследования и результаты?

Цена до р. Котята - домашние любимцы. Цена от р. Всё обо всём Клуб путешественника Кулинарная книга Творчество, хобби Поговорим Милосердие А не выпить ли нам по маленькой Похожие темы хочу все знать от Anzhalika в разделе Здравствуйте. Как о них знать и как их различать?! Проектирование и поставка промышленных зданий и сооружений из металлоконструкций.


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